An advanced mouse model for human skin wound healing
نویسندگان
چکیده
منابع مشابه
- MODELS TO INVESTIGATE HUMAN WOUND HEALING - Development of an in vivo mouse model to study human wound healing
Scar formation is a frequently occurring unwanted result of healing of a skin wound. The mechanisms causing scar formation are not fully understood, although many studies have attempted to unravel this issue. Most of these studies were performed in animals or in in vitro models, but both have major drawbacks. In the present study we aimed to develop a representative model in which the human wou...
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Denervated skin could result in impaired healing of wounds, such as decubitus ulcers and diabetic foot ulcers. Other studies indicated that cutaneous fiber density is reduced after inner nerve transection and that neuropeptide level depletes after denervation, leading to reduced cell proliferation around the wound and thus wound healing problems. Recent studies have revealed that skin-derived p...
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PURPOSE To establish a new mouse model for wound healing studies on hemophilia A. METHODS Total 54 male mice with different genotypes including wild-type nude mice, heterozygous mice (FVIII-/-/Nu) and FVIII deficient mice (FVIII-/-) were generated and verified by PCR. Mice were subjected to wound healing research by making a 5 mm-thickness wound on mice skin and applying recombinant human epi...
متن کاملBioprinting of skin constructs for wound healing
Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the ...
متن کاملAngiogenesis Is Induced and Wound Size Is Reduced by Electrical Stimulation in an Acute Wound Healing Model in Human Skin
Angiogenesis is critical for wound healing. Insufficient angiogenesis can result in impaired wound healing and chronic wound formation. Electrical stimulation (ES) has been shown to enhance angiogenesis. We previously showed that ES enhanced angiogenesis in acute wounds at one time point (day 14). The aim of this study was to further evaluate the role of ES in affecting angiogenesis during the ...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2017
ISSN: 0906-6705
DOI: 10.1111/exd.13258